Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction
نویسندگان
چکیده
منابع مشابه
TNNI3K, a Cardiac-Specific Kinase, Promotes Physiological Cardiac Hypertrophy in Transgenic Mice
PURPOSE Protein kinase plays an essential role in controlling cardiac growth and hypertrophic remodeling. The cardiac troponin I-interacting kinase (TNNI3K), a novel cardiac specific kinase, is associated with cardiomyocyte hypertrophy. However, the precise function of TNNI3K in regulating cardiac remodeling has remained controversial. METHODS AND RESULTS In a rat model of cardiac hypertrophy...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2013
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2012.10.004